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For instance, the gene products of glycoproteins J and D (gJ, gD) have been reported to modulate cellular apoptosis during HSV-1 infection of the SK-N-SH human neuron cell line (neuroblastoma), as mutant viruses lacking any of the genes encoding for these proteins led to cell apoptosis early after infection, which was abolished when gD and gJ were complemented in trans (Zhou et al., 2000)
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Natural compounds (e.g., resveratrol, curcumin, polydatin), traditional therapies (e.g., Tuina), and exosome-based interventions activate protective autophagy via mTOR-dependent or AMPK-mediated pathways, attenuating pain, synovitis, and cartilage damage in preclinical models (Section 3.4 discusses the stage-dependent dual role of autophagy in KOA in detail
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