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Once pathological aetiologias have been discarded, it is relevant to question the supply and status of vitamins and minerals and to provide nutritional advice first aiming at promoting balanced food choices, then focusing on the use of vitamin and mineral supplementation

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The structure and neurochemistry of the ENS resemble that of the CNS, which is why it often is referred to as the “second brain”, and thereby, any mechanisms implicated in CNS dysfunction may also result in ENS dysfunction or vice versa [44,45]

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