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It has been used: As part of the treatment for cyanide poisoning To dye tissues during surgery to determine tumors To relieve pain caused by oral mucositis To identify orthopedic injury to joint capsules To treat malaria before modern treatments were developed To treat encephalopathy, or confusion caused by chemotherapy Exploring other uses for methylene blue Earlier in my career, while working in emergency medicine, I read two papers that discussed using methylene blue as part of photodynamic therapy for lichen planus, a type of precancerous lesion in the mouth

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L., Syversen T., Shanker G., Sonnewald U., and Aschner M., “In Vitro Uptake of Glutamate in GLAST‐ and GLT‐1‐Transfected Mutant CHO‐K1 Cells Is Inhibited by the Ethylmercury‐Containing Preservative Thimerosal,” Biological Trace Element Research 105 (2005): 71–86, 10.1385/bter:105:1-3:071