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In a study conducted in 2012, where 252 patients with colorectal cancer and 293 subjects with negative results from colonoscopy were screened, Cologuard (KRAS mutation + fecal hemoglobin + NDRG4 and BMP3 methylation) exhibited a sensitivity of 85% and specificity of 90% ( 2.1.5 MGMT MGMT is a greatly efficient DNA methyltransferase that transfers methyl groups from DNA molecules to their own amino acid residues (Wick et al., 2012)
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