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The Role of Fibrinaloid Microclots in POTS Although the origins of our discoveries that blood could clot into a very anomalous form lie earlier- in observations using the electron microscope (e.g., [143,144,145,146])- it was not until 2016 [147] that we determined using fluorescence microscopy that these anomalous forms were in fact amyloid in nature [148,149,150,151,152], that they could be induced by highly substoichiometric amounts of bacterial lipopolysaccharide [147], and that the electron and optical microscopies were congruent [153]