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doi: 10.3389/fcimb.2025.1673512 Received 26 July 2025 Revised 29 October 2025 Accepted 14 November 2025 Published 27 February 2026 Volume 15 - 2025 Edited by Soumyadev Sarkar, Arizona State University, United States Reviewed by Yoshihiko Tanaka, Fukuoka Dental College, Japan Chiara Scapoli, University of Ferrara, Italy Narjess Bostanghadiri, Tehran University of Medical Sciences, Iran Updates Copyright © 2026 Gan, Chen, Zheng, Long, Cheng, Sulaiman and Huang

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Replacing the sulfonic acid at position R 1 with a sulfonamide group ( 33 ) resulted in a drastic decrease in solubility of the fragment with a concomitant reduction of binding to TRF1 TRFH by CPMG, whilst the dimethyl sulfonamide 35 or the even bigger benzyl sulfonamide 36 showed an even poorer solubility and a loss of TRF1 TRFH binding (Table 1)