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They secrete a range of cytokines and growth factors, including TGF-β and Platelet derived growth factor (PDGF), which are instrumental in promoting fibroblast activation and ECM production, key events in fibrosis development (98)
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Treatment was delivered intraperitoneally twice a week for 2 mo, starting at 4–5 wk of age, using the dosage of 20 mg/kg, as for the other experiments described here
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