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With mouse models not being able to accurately recapitulate human neurodevelopmental periods, another translational step could be developing models of haploinsufficiency within NHPs—something that has already been established for the SHANK3 and MECP2 genes within cynomolgus macaques [35, 36]
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they could diffuse into the cytosol, or they could react with GSH in the ER, leading to an increase in GSSG
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